Dimethyl sulphoxide as leaving group: applications in transition metal chemotherapy
Abstract
Sulphur-bound dimethyl sulphoxide (DMSO) hydrolyses slowly in complexes of platinum; incorporation of DMSO into molecular species such as [Pt(diamine)(DMSO)2]2+ results in water-soluble, less toxic derivatives with equivalent chemotherapeutic activity of those of the parent chloro-complexes.