Issue 21, 1982
From the journal:

Journal of the Chemical Society, Chemical Communications

Unusual effect of a mixed solvent on the asymmetric reduction of chiral α-keto-amides with sodium borohydride

Kenso Soai,   Kazuyuki Komiya,   Yasuhiko Shigematsu,   Hitoshi Hasegawa  and  Atsuhiro Ookawa  

Abstract

The mixed solvent tetrahydrofuran + methanol (99 : 1) was much more effective than the individual solvents in the asymmetric reduction of chiral α-keto-amides with sodium borohydride; this solvent effect in asymmetric induction is unprecedented.

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Article information

DOI
https://doi.org/10.1039/C39820001282
Article type
Paper

J. Chem. Soc., Chem. Commun., 1982, 1282-1283

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Unusual effect of a mixed solvent on the asymmetric reduction of chiral α-keto-amides with sodium borohydride

K. Soai, K. Komiya, Y. Shigematsu, H. Hasegawa and A. Ookawa, J. Chem. Soc., Chem. Commun., 1982, 1282 DOI: 10.1039/C39820001282

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