Issue 2, 1986

Stereospecificity of carbon–sulphur bond formation in penicillin biosynthesis

Abstract

The conversion of the tripeptide (L-α-amino-δ-adipoyl)-L-cysteinyl-D-valine (α-amino-δ-adipoyl = 5-amino-5-carboxypentanoyl) into isopenicillin N by the enzyme isopenicillin N synthetase has been shown to proceed with complete retention of stereochemistry; a similar result was observed during penicillin formation with isoleucinyl and allo-isoleucinyl tripeptides.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1986, 110-113

Stereospecificity of carbon–sulphur bond formation in penicillin biosynthesis

J. E. Baldwin, R. M. Adlington, B. P. Domayne-Hayman, H. Ting and N. J. Turner, J. Chem. Soc., Chem. Commun., 1986, 110 DOI: 10.1039/C39860000110

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