Palladium(II) catalysed construction of tetrasubstituted carbon centres, and spiro and bridged-ring compounds from enamides of 2-lodobenzoic acids

Abstract

Various N-vinyl- and N-allyl-amides of 2-iodobenzoic acid undergo catalytic cyclisation in the presence of tetraethylammonium chloride and a palladium acetate-based catalyst system to generate a range of synthetically useful structural features including tetrasubstituted carbon centres, and spiro- and bridged-ring compounds, and in which 5-exo-trig cyclisations are kinetically favoured.