Issue 5, 1987

Asymmetric synthesis of clerodane diterpenoids: total synthesis of (–)-methyl kolavenate

Abstract

The asymmetric synthesis of (8R,9S,10R)-4,8,9-trimethyl-9-vinyl-Δ4-3-octalone, a versatile intermediate for the syntheses of both trans- and cis-neo-clerodane diterpenoids, has been achieved by extension of Ender's asymmetric alkylation, and its utility is exemplified by the total synthesis of (–)-methyl kolavenate, the first example of a clerodane diterpenoid in optically active form.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1987, 358-359

Asymmetric synthesis of clerodane diterpenoids: total synthesis of (–)-methyl kolavenate

H. Iio, M. Monden, K. Okada and T. Tokoroyama, J. Chem. Soc., Chem. Commun., 1987, 358 DOI: 10.1039/C39870000358

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements