Issue 10, 1994

Synthesis of a key intermediate for preparation of 4,5-didehydro prostaglandins containing an allenyl side-chain group via two-component coupling process. Synthesis of enprostil

Abstract

Enone 8, a key intermediate in the preparation of 4,5-didehydro prostaglandins via a two component coupling process, is prepared efficiently from readily available enone 6; the synthesis of enprostil, an antiulcer agent developed by Syntex, using enone 8 is also described.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1994, 1251-1252

Synthesis of a key intermediate for preparation of 4,5-didehydro prostaglandins containing an allenyl side-chain group via two-component coupling process. Synthesis of enprostil

N. Ono, Y. Kawanaka, Y. Yoshida and F. Sato, J. Chem. Soc., Chem. Commun., 1994, 1251 DOI: 10.1039/C39940001251

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