Issue 11, 1994
From the journal:

Journal of the Chemical Society, Chemical Communications

Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

Neville H. Nicholson,   Keith H. Baggaley,   Robert Cassels,   Mark Davison,   Stephen W. Elson,   Mark Fulston,   John W. Tyler  and  Stefan R. Woroniecki  

Abstract

(3R, 5R) Clavulanate-9-aldehyde 1 has been detected in Streptomyces clavuligerus and an NADPH dependent dehydrogenase capable of reducing 1 to clavulanic acid 2 has been isolated from this organism.

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Article information

DOI
https://doi.org/10.1039/C39940001281
Article type
Paper

J. Chem. Soc., Chem. Commun., 1994, 1281-1282

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Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

N. H. Nicholson, K. H. Baggaley, R. Cassels, M. Davison, S. W. Elson, M. Fulston, J. W. Tyler and S. R. Woroniecki, J. Chem. Soc., Chem. Commun., 1994, 1281 DOI: 10.1039/C39940001281

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