Issue 21, 1995

Carbonylative coupling of an amino acid-derived organozinc reagent with functionalized aryl iodides: synthesis of kynurenine

Abstract

The utility of the palladium(0) catalysed reaction of the serine-derived organozinc reagent 6 with functionalized aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo α-amino acids 8 is illustrated by a short synthesis of L-kynurenine.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 2207-2208

Carbonylative coupling of an amino acid-derived organozinc reagent with functionalized aryl iodides: synthesis of kynurenine

R. F. W. Jackson, D. Turner and M. H. Block, J. Chem. Soc., Chem. Commun., 1995, 2207 DOI: 10.1039/C39950002207

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements