Issue 11, 2013

Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy

Abstract

Presented here is a novel method of in vivo pH sensing utilizing a hybrid optical imaging technique, photoacoustic imaging (PAI), and pH sensitive polymeric nanoprobes. Nanoprobes with hydrophobic core containing a pH sensitive dye were synthesized and used to measure the pH level ex vivo first and then in vivo by performing experiments on a rat joint model, with an achieved precision of less than 0.1 pH units. The ability of the hydrophobic functional groups in the polyacrylamide matrix to shield the molecular dye from being affected by the proteins in the plasma, and prevent the dye from leaching out, is also demonstrated.

Graphical abstract: Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2013
Accepted
05 Apr 2013
First published
05 Apr 2013

Analyst, 2013,138, 3126-3130

Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy

A. Ray, H. K. Yoon, Y. E. Koo Lee, R. Kopelman and X. Wang, Analyst, 2013, 138, 3126 DOI: 10.1039/C3AN00093A

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