Issue 1, 2014
From the journal:

Analyst

Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy†

Adrian Ghita,a   Flavius C. Pascut,a   Virginie Sottileb  and  Ioan Notingher*a  

* Corresponding authors

a School of Physics and Astronomy, University of Nottingham, Nottingham, UK
E-mail: ioan.notingher@nottingham.ac.uk

b Wolfson centre for stem cells, Tissue Engineering and Modelling (STEM), School of Medicine, University of Nottingham, Nottingham, UK
E-mail: virginie.sottile@nottingham.ac.uk

Abstract

Raman microscopy was used as a label-free method to study the mineralisation of bone nodules formed by mesenchymal stem cells cultured in osteogenic medium in vitro. Monitoring individual bone nodules over 28 days revealed temporal and spatial changes in the crystalline phase of the hydroxyapatite components of the nodules.

Graphical abstract: Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy

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Article information

DOI
https://doi.org/10.1039/C3AN01716H
Article type
Communication
Submitted
09 Sep 2013
Accepted
15 Oct 2013
First published
16 Oct 2013

Analyst, 2014,139, 55-58

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Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy

A. Ghita, F. C. Pascut, V. Sottile and I. Notingher, Analyst, 2014, 139, 55 DOI: 10.1039/C3AN01716H

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