Issue 7, 2014
From the journal:

Analytical Methods

An autonomous T-rich DNA machine based lateral flow biosensor for amplified visual detection of mercury ions†

Jie Liu,‡ac   Lingbo Chen,‡ab   Junhua Chen,a   Chenchen Ge,a   Zhiyuan Fang,a   Lin Wang,a   Xuerong Xing*ad  and  Lingwen Zeng*a  

* Corresponding authors

a Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
E-mail: zeng_lingwen@gibh.ac.cn
Tel: +86 20 32015312

b School of Life Sciences, Anhui University, Hefei, Anhui 230601, China

c Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

d Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 XiQiDao, Tianjin Airport Economic Park, Tianjin 300308, China
E-mail: xin_xuerong@gibh.ac.cn

Abstract

An autonomous thymine rich DNA machine as an amplification unit was developed for the sensitive detection of mercury ions with high specificity. Combined with a lateral flow biosensor, the amplified signal of Hg2+ can be read out by the naked eye with a detection limit of 5 nM.

Graphical abstract: An autonomous T-rich DNA machine based lateral flow biosensor for amplified visual detection of mercury ions

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Article information

DOI
https://doi.org/10.1039/C3AY42266F
Article type
Communication
Submitted
18 Dec 2013
Accepted
16 Jan 2014
First published
17 Jan 2014

Anal. Methods, 2014,6, 2024-2027

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An autonomous T-rich DNA machine based lateral flow biosensor for amplified visual detection of mercury ions

J. Liu, L. Chen, J. Chen, C. Ge, Z. Fang, L. Wang, X. Xing and L. Zeng, Anal. Methods, 2014, 6, 2024 DOI: 10.1039/C3AY42266F

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