Issue 32, 2013

A Pd(ii)-catalyzed asymmetric approach toward chiral [3.3.1]-bicyclic ketals using 2-hydroxyphenylboronic acid as a pro-bis(nucleophile)

Abstract

Enantioselective Pd(II)-catalyzed construction of [3.3.1]-bicyclic ketals from 2-hydroxyphenylboronic acid 1 and enone 3 is reported, yielding enantioenriched [3.3.1]-bicyclic ketals in up to 97% yields and 98% ee.

Graphical abstract: A Pd(ii)-catalyzed asymmetric approach toward chiral [3.3.1]-bicyclic ketals using 2-hydroxyphenylboronic acid as a pro-bis(nucleophile)

Supplementary files

Article information

Article type
Communication
Submitted
13 Jan 2013
Accepted
07 Mar 2013
First published
07 Mar 2013

Chem. Commun., 2013,49, 3360-3362

A Pd(II)-catalyzed asymmetric approach toward chiral [3.3.1]-bicyclic ketals using 2-hydroxyphenylboronic acid as a pro-bis(nucleophile)

F. Wang, F. Chen, M. Qu, T. Li, Y. Liu and M. Shi, Chem. Commun., 2013, 49, 3360 DOI: 10.1039/C3CC00295K

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