Issue 25, 2013

Protein corona significantly reduces active targeting yield

Abstract

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

Graphical abstract: Protein corona significantly reduces active targeting yield

Supplementary files

Article information

Article type
Communication
Submitted
06 Oct 2012
Accepted
11 Feb 2013
First published
12 Feb 2013

Chem. Commun., 2013,49, 2557-2559

Protein corona significantly reduces active targeting yield

V. Mirshafiee, M. Mahmoudi, K. Lou, J. Cheng and M. L. Kraft, Chem. Commun., 2013, 49, 2557 DOI: 10.1039/C3CC37307J

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