No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides

Joong-Hyun Chun; Cheryl L. Morse; Frederick T. Chin; Victor W. Pike

doi:10.1039/C3CC37795D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

No-carrier-added [¹⁸F]fluoroarenes from the radiofluorination of diaryl sulfoxides†

Joong-Hyun Chun,^a Cheryl L. Morse,^a Frederick T. Chin ‡^a and Victor W. Pike*^a

Author affiliations

* Corresponding authors

^a Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, MD 20892-1003, USA
E-mail: pikev@mail.nih.gov
Fax: +1 301 480 5112
Tel: +1 301 594 5986

Abstract

No-carrier-added [¹⁸F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [¹⁸F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[¹⁸F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel ¹⁸F-labeling synthons and PET radiotracers.

Download options Please wait...

Supplementary files

Supplementary information PDF (3871K)

Article information

DOI: https://doi.org/10.1039/C3CC37795D
Article type: Communication
Submitted: 26 Oct 2012
Accepted: 29 Jan 2013
First published: 30 Jan 2013

Download Citation

Chem. Commun., 2013,49, 2151-2153

Permissions

Request permissions

No-carrier-added [¹⁸F]fluoroarenes from the radiofluorination of diaryl sulfoxides

J. Chun, C. L. Morse, F. T. Chin and V. W. Pike, Chem. Commun., 2013, 49, 2151 DOI: 10.1039/C3CC37795D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications