A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

Ting Guo; Lei Cui; Jiaoning Shen; Rui Wang; Weiping Zhu; Yufang Xu; Xuhong Qian

doi:10.1039/C3CC38471C

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A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells†

Ting Guo,^a Lei Cui,^a Jiaoning Shen,^a Rui Wang,^a Weiping Zhu,^a Yufang Xu*^a and Xuhong Qian*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, China
E-mail: xhqian@ecsut.edu.cn, yfxu@ecust.edu.cn
Fax: +86-21-64252603

Abstract

A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO⁻). Upon addition of ClO⁻, significant changes in fluorescence emission intensity at two discrete wavelengths were observed. Meanwhile OONO⁻ led to only a single-channel fluorescence enhancement. This feature makes it a clear advantage in distinguishing ClO⁻, RNS from other ROS.

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Article information

DOI: https://doi.org/10.1039/C3CC38471C
Article type: Communication
Submitted: 25 Nov 2012
Accepted: 17 Jan 2013
First published: 29 Jan 2013

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Chem. Commun., 2013,49, 1862-1864

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A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

T. Guo, L. Cui, J. Shen, R. Wang, W. Zhu, Y. Xu and X. Qian, Chem. Commun., 2013, 49, 1862 DOI: 10.1039/C3CC38471C

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Chemical Communications

A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells†

Abstract

Supplementary files

Article information

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A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

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