Issue 20, 2013

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

Graphical abstract: Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug 2012
Accepted
18 Jan 2013
First published
21 Jan 2013

Chem. Commun., 2013,49, 2010-2012

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

K. Kim, D. Kim, T. Lee, J. Y. Yhee, B. Kim, I. C. Kwon and D. Ahn, Chem. Commun., 2013, 49, 2010 DOI: 10.1039/C3CC38693G

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