Issue 26, 2013
From the journal:

Chemical Communications

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization†

Aseem Mishra,‡a   Anurag Misra,‡b   T. Sri Vaishnavi,a   Chaitanya Thota,a   Madhvi Gupta,a   Suryanarayanarao Ramakumar*b  and  Virander Singh Chauhan*a  

* Corresponding authors

a International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
E-mail: virander@icgeb.res.in
Fax: +91-11-26742316
Tel: +91-11-26741358

b Department of Physics, Indian Institute of Science, Bangalore 560012, India
E-mail: ramak@physics.iisc.ernet.in
Tel: +91-80-22932312

Abstract

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

Graphical abstract: Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

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Article information

DOI
https://doi.org/10.1039/C3CC38982K
Article type
Communication
Submitted
16 Dec 2012
Accepted
11 Feb 2013
First published
13 Feb 2013
This article is Open Access

Chem. Commun., 2013,49, 2688-2690

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Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

A. Mishra, A. Misra, T. Sri Vaishnavi, C. Thota, M. Gupta, S. Ramakumar and V. S. Chauhan, Chem. Commun., 2013, 49, 2688 DOI: 10.1039/C3CC38982K

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