Issue 30, 2013
From the journal:

Chemical Communications

Monitoring fast reactions by spatially-selective and frequency-shifted continuous NMR spectroscopy: application to rapid-injection protein unfolding†

Gabriel E. Wagner,a   Peyman Sakhaii,b   Wolfgang Bermelc  and  Klaus Zangger*a  

* Corresponding authors

a Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
E-mail: klaus.zangger@uni-graz.at

b NMR Laboratory of C&BD, Industriepark Hoechst, Building D770, Labor 204, 65926 Frankfurt/Main, Germany

c Bruker BioSpin GmbH, 76287 Rheinstetten, Germany

Abstract

The repetition rate of an NMR experiment is usually limited by the longitudinal relaxation times of the investigated molecule. Here we show that continuous excitation and data acquisition, without any interscan delay, is possible by a spatially resolved experiment where different nuclei are excited in consecutive scans.

Graphical abstract: Monitoring fast reactions by spatially-selective and frequency-shifted continuous NMR spectroscopy: application to rapid-injection protein unfolding

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Article information

DOI
https://doi.org/10.1039/C3CC39107H
Article type
Communication
Submitted
20 Dec 2012
Accepted
01 Mar 2013
First published
01 Mar 2013
This article is Open Access

Chem. Commun., 2013,49, 3155-3157

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Monitoring fast reactions by spatially-selective and frequency-shifted continuous NMR spectroscopy: application to rapid-injection protein unfolding

G. E. Wagner, P. Sakhaii, W. Bermel and K. Zangger, Chem. Commun., 2013, 49, 3155 DOI: 10.1039/C3CC39107H

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