Issue 32, 2013

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Abstract

Organometallic RuII, OsII and RhIII complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Graphical abstract: Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Supplementary files

Article information

Article type
Communication
Submitted
18 Jan 2013
Accepted
06 Mar 2013
First published
06 Mar 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 3348-3350

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

W. Kandioller, E. Balsano, S. M. Meier, U. Jungwirth, S. Göschl, A. Roller, M. A. Jakupec, W. Berger, B. K. Keppler and C. G. Hartinger, Chem. Commun., 2013, 49, 3348 DOI: 10.1039/C3CC40432C

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