Issue 26, 2013
From the journal:

Chemical Communications

Peptide directed transmembrane transport and nuclear localization of Ru(ii) polypyridyl complexes in mammalian cells†

Lorraine Blackmore,ab   Roisin Moriarty,a   Ciaran Dolan,a   Kellie Adamson,ab   Robert J. Forster,a   Marc Devocelle*b  and  Tia E. Keyes*a  

* Corresponding authors

a National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland
E-mail: tia.keyes@dcu.ie

b Centre for Synthesis and Chemical Biology, Dept. of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland
E-mail: mdevocelle@rcsi.ie

Abstract

The targeted delivery of luminescent Ru(II) polypyridyl complexes to the nucleus of live mammalian cells by a Nuclear Localisation Signal (NLS) peptide; NF-κB is demonstrated.

Graphical abstract: Peptide directed transmembrane transport and nuclear localization of Ru(ii) polypyridyl complexes in mammalian cells

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Article information

DOI
https://doi.org/10.1039/C3CC40453F
Article type
Communication
Submitted
18 Jan 2013
Accepted
12 Feb 2013
First published
13 Feb 2013

Chem. Commun., 2013,49, 2658-2660

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Peptide directed transmembrane transport and nuclear localization of Ru(II) polypyridyl complexes in mammalian cells

L. Blackmore, R. Moriarty, C. Dolan, K. Adamson, R. J. Forster, M. Devocelle and T. E. Keyes, Chem. Commun., 2013, 49, 2658 DOI: 10.1039/C3CC40453F

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