Issue 46, 2013
From the journal:

Chemical Communications

A bioreducible linear poly(β-amino ester) for siRNA delivery†

Kristen L. Kozielski,a   Stephany Y. Tzenga  and  Jordan J. Green*a  

* Corresponding authors

a Department of Biomedical Engineering, Department of Ophthalmology, the Institute for Nanobiotechnology, and the Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, 400 N. Broadway/Smith Building Room 5017, Baltimore, Maryland 21231, USA
E-mail: green@jhu.edu
Tel: +1 410-614-9113

Abstract

Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

Graphical abstract: A bioreducible linear poly(β-amino ester) for siRNA delivery

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Article information

DOI
https://doi.org/10.1039/C3CC40718G
Article type
Communication
Submitted
28 Jan 2013
Accepted
11 Apr 2013
First published
11 Apr 2013

Chem. Commun., 2013,49, 5319-5321

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A bioreducible linear poly(β-amino ester) for siRNA delivery

K. L. Kozielski, S. Y. Tzeng and J. J. Green, Chem. Commun., 2013, 49, 5319 DOI: 10.1039/C3CC40718G

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