Translating the concept of peptidelabeling with 5-deoxy-5-[18F]fluororibose into preclinical practice: 18F-labeling of Siglec-9 peptide for PET imaging of inflammation

Xiang-Guo Li; Anu Autio; Helena Ahtinen; Kerttuli Helariutta; Heidi Liljenbäck; Sirpa Jalkanen; Anne Roivainen; Anu J. Airaksinen

doi:10.1039/C3CC40738A

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Translating the concept of peptidelabeling with 5-deoxy-5-[¹⁸F]fluororibose into preclinical practice: ¹⁸F-labeling of Siglec-9 peptide for PET imaging of inflammation†

Xiang-Guo Li,*^ab Anu Autio,^b Helena Ahtinen,^b Kerttuli Helariutta,^c Heidi Liljenbäck,^bd Sirpa Jalkanen,^e Anne Roivainen*^bd and Anu J. Airaksinen*^c

Author affiliations

* Corresponding authors

^a Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland
E-mail: xiali@utu.fi

^b Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland
E-mail: anne.roivainen@utu.fi

^c Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland
E-mail: anu.airaksinen@helsinki.fi

^d Turku Center for Disease Modeling, University of Turku, FI-20014 Turku, Finland

^e MediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, FI-20014 Turku, Finland

Abstract

Peptide glycosylation with 5-deoxy-5-[¹⁸F]fluororibose was translated into preclinical settings. The novel ¹⁸F-labeled Siglec-9 peptide was produced using an automated synthesis procedure. The ¹⁸F-labeled Siglec-9 peptide showed favorable binding in the animal model of inflammation in vivo.

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Article information

DOI: https://doi.org/10.1039/C3CC40738A
Article type: Communication
Submitted: 29 Jan 2013
Accepted: 15 Mar 2013
First published: 15 Mar 2013
This article is Open Access

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Chem. Commun., 2013,49, 3682-3684

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Translating the concept of peptidelabeling with 5-deoxy-5-[¹⁸F]fluororibose into preclinical practice: ¹⁸F-labeling of Siglec-9 peptide for PET imaging of inflammation

X. Li, A. Autio, H. Ahtinen, K. Helariutta, H. Liljenbäck, S. Jalkanen, A. Roivainen and A. J. Airaksinen, Chem. Commun., 2013, 49, 3682 DOI: 10.1039/C3CC40738A

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