Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Matthias M. Herth; Valdemar L. Andersen; Szabolcs Lehel; Jacob Madsen; Gitte M. Knudsen; Jesper L. Kristensen

doi:10.1039/C3CC41027G

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Development of a ¹¹C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation†

Matthias M. Herth,*^abc Valdemar L. Andersen,^abc Szabolcs Lehel,^c Jacob Madsen,^c Gitte M. Knudsen^a and Jesper L. Kristensen^b

Author affiliations

* Corresponding authors

^a Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
E-mail: matthias.herth@nru.dk
Fax: +45 3545 6713
Tel: +45 3545 6711

^b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark
Fax: +45 3533 6041
Tel: +45 3533 6487

^c PET and Cyclotron Unit, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Fax: +45 3545 3545
Tel: +45 3545 8621

Abstract

Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first ¹¹C-labelled tetrazine and its reaction with trans-cyclooctenol.

Download options Please wait...

Supplementary files

Supplementary information PDF (827K)

Article information

DOI: https://doi.org/10.1039/C3CC41027G
Article type: Communication
Submitted: 06 Feb 2013
Accepted: 18 Mar 2013
First published: 18 Mar 2013

Download Citation

Chem. Commun., 2013,49, 3805-3807

Permissions

Request permissions

Development of a ¹¹C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

M. M. Herth, V. L. Andersen, S. Lehel, J. Madsen, G. M. Knudsen and J. L. Kristensen, Chem. Commun., 2013, 49, 3805 DOI: 10.1039/C3CC41027G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications