Issue 41, 2013

Pd-catalyzed C3-selective arylation of pyridines with phenyl tosylates

Abstract

We have discovered that phenyl tosylates can be used to arylate pyridines at the C3-position using a Pd(OAc)2–1,10-phenanthroline catalyst system. We also discovered that the reaction of 4-methylpyridine with naphthyl tosylates occurred on the methyl group instead of at the C3-position.

Graphical abstract: Pd-catalyzed C3-selective arylation of pyridines with phenyl tosylates

Supplementary files

Article information

Article type
Communication
Submitted
07 Feb 2013
Accepted
26 Mar 2013
First published
28 Mar 2013

Chem. Commun., 2013,49, 4634-4636

Pd-catalyzed C3-selective arylation of pyridines with phenyl tosylates

F. Dai, Q. Gui, J. Liu, Z. Yang, X. Chen, R. Guo and Z. Tan, Chem. Commun., 2013, 49, 4634 DOI: 10.1039/C3CC41066H

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