Issue 48, 2013

Structure of matrix metalloproteinase-3 with a platinum-based inhibitor

Abstract

An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1′ specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).

Graphical abstract: Structure of matrix metalloproteinase-3 with a platinum-based inhibitor

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2013
Accepted
24 Apr 2013
First published
25 Apr 2013

Chem. Commun., 2013,49, 5492-5494

Structure of matrix metalloproteinase-3 with a platinum-based inhibitor

B. D. Belviso, R. Caliandro, D. Siliqi, V. Calderone, F. Arnesano and G. Natile, Chem. Commun., 2013, 49, 5492 DOI: 10.1039/C3CC41278D

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