Issue 47, 2013

Dual enzyme responsive microcapsules simulating an “OR” logic gate for biologically triggered drug delivery applications

Abstract

Hollow microcapsules capable of disintegrating in response to dual biological stimuli have been synthesized from two FDA approved drug molecules. The capsules fabricated from protamine and chondroitin sulphate disintegrate in the presence of either trypsin or hyaluronidase enzymes, which are documented to be simultaneously over-expressed under some pathological conditions.

Graphical abstract: Dual enzyme responsive microcapsules simulating an “OR” logic gate for biologically triggered drug delivery applications

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2013
Accepted
24 Apr 2013
First published
25 Apr 2013

Chem. Commun., 2013,49, 5390-5392

Dual enzyme responsive microcapsules simulating an “OR” logic gate for biologically triggered drug delivery applications

K. Radhakrishnan, J. Tripathy and A. M. Raichur, Chem. Commun., 2013, 49, 5390 DOI: 10.1039/C3CC42017E

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