Issue 51, 2013
From the journal:

Chemical Communications

A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices†

Sabrina Capece,a   Ester Chiessi,a   Roberta Cavalli,b   Pierangela Giustetto,cd   Dmitry Grishenkove  and  Gaio Paradossi*a  

* Corresponding authors

a Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
E-mail: paradossi@stc.uniroma2.it
Fax: +39 06 7259 4328
Tel: +39 06 7259 4464

b Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via P. Giuria 9, 10125 Torino, Italy

c University of Torino, Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, Torino, Italy

d Center for Preclinical Imaging, Colleretto Giacosa, TO, Italy

e Division of Medical Engineering, School of Technology and Health, Royal Institute of Technology, KTH, Alfred Nobels allé 10, SE-141 52 Huddinge, Sweden

Abstract

Fabrication of multifunctional ultrasound contrast agents (UCAs) has been recently addressed by several research groups. A versatile strategy for the synthesis of UCA precursors in the form of biodegradable vesicles with a biocompatible crosslinked polymer shell is described. Upon ultrasound irradiation, acoustic droplet vaporization transforms such particles into microbubbles behaving as UCAs. This proof of concept entails the features of a potential theranostic microdevice.

Graphical abstract: A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC42037J
Article type
Communication
Submitted
20 Mar 2013
Accepted
06 May 2013
First published
07 May 2013

Chem. Commun., 2013,49, 5763-5765

Permissions

Request permissions

A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices

S. Capece, E. Chiessi, R. Cavalli, P. Giustetto, D. Grishenkov and G. Paradossi, Chem. Commun., 2013, 49, 5763 DOI: 10.1039/C3CC42037J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements