Issue 59, 2013
From the journal:

Chemical Communications

Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives†

G. Sathish Kumar,a   R. Arun Kumar,a   P. Santhosh Kumar,a   N. Veera Reddy,a   K. Vijaya Kumar,a   M. Lakshmi Kantam,a   S. Prabhakarb  and  K. Rajender Reddy*a  

* Corresponding authors

a Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology (CSIR-IICT), Tarnaka, Hyderabad-500 607, India
E-mail: rajender@iict.res.in, rajenderkallu@yahoo.com
Fax: +91-040-27160921

b National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500607, India

Abstract

Direct access to unsymmetrical urea derivatives via copper catalysed C–H/N–H coupling of formamides with amines has been developed at room temperature. This protocol is also applied to the synthesis of chiral urea derivatives.

Graphical abstract: Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives

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Article information

DOI
https://doi.org/10.1039/C3CC42381F
Article type
Communication
Submitted
03 Apr 2013
Accepted
04 Jun 2013
First published
04 Jun 2013

Chem. Commun., 2013,49, 6686-6688

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Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives

G. S. Kumar, R. A. Kumar, P. S. Kumar, N. V. Reddy, K. V. Kumar, M. L. Kantam, S. Prabhakar and K. R. Reddy, Chem. Commun., 2013, 49, 6686 DOI: 10.1039/C3CC42381F

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