Issue 50, 2013

Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

Abstract

A mild and efficient copper-catalyzed trifluoromethylation reaction which involves the cyclization of oximes has been developed. This method provides a convenient access to a variety of useful CF3-containing 4,5-dihydroisoxazoles by constructing a C–CF3 bond and a C–O bond in one step.

Graphical abstract: Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

Supplementary files

Article information

Article type
Communication
Submitted
09 Apr 2013
Accepted
03 May 2013
First published
03 May 2013

Chem. Commun., 2013,49, 5687-5689

Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines

Y. He, L. Li, Y. Yang, Y. Wang, J. Luo, X. Liu and Y. Liang, Chem. Commun., 2013, 49, 5687 DOI: 10.1039/C3CC42588F

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