Issue 54, 2013

Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids

Abstract

Designed and synthesized porphyrin–globotriose hybrids effectively degraded verotoxin-1, which causes severe bloody diarrhoea and fetal hemolytic uremic syndrome (HUS). Degradation was achieved using long-wavelength UV or visible light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrids neutralized the cytotoxicity of verotoxin upon photo-irradiation.

Graphical abstract: Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids

Supplementary files

Article information

Article type
Communication
Submitted
22 Apr 2013
Accepted
15 May 2013
First published
17 May 2013

Chem. Commun., 2013,49, 6027-6029

Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids

A. Okochi, S. Tanimoto, D. Takahashi and K. Toshima, Chem. Commun., 2013, 49, 6027 DOI: 10.1039/C3CC42957A

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