A reversible ratiometric sensor for intracellular Cu2+ imaging: metal coordination-altered FRET in a dual fluorophore hybrid

Yuncong Chen; Chengcheng Zhu; Jiajie Cen; Jing Li; Weijiang He; Yang Jiao; Zijian Guo

doi:10.1039/C3CC42959H

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A reversible ratiometric sensor for intracellular Cu²⁺ imaging: metal coordination-altered FRET in a dual fluorophore hybrid†

Yuncong Chen,^a Chengcheng Zhu,^a Jiajie Cen,^a Jing Li,^a Weijiang He,*^a Yang Jiao^a and Zijian Guo*^a

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* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: heweij69@nju.edu.cn, zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83597066

Abstract

ICT fluorophore benzoxadiazole with its electron-donating group modified as a Cu²⁺ chelator was conjugated with coumarin to construct a new ratiometric sensor with reversible intracellular Cu²⁺ imaging ability.

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Article information

DOI: https://doi.org/10.1039/C3CC42959H
Article type: Communication
Submitted: 22 Apr 2013
Accepted: 24 Jun 2013
First published: 24 Jun 2013

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Chem. Commun., 2013,49, 7632-7634

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A reversible ratiometric sensor for intracellular Cu²⁺ imaging: metal coordination-altered FRET in a dual fluorophore hybrid

Y. Chen, C. Zhu, J. Cen, J. Li, W. He, Y. Jiao and Z. Guo, Chem. Commun., 2013, 49, 7632 DOI: 10.1039/C3CC42959H

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Chemical Communications