Issue 52, 2013
From the journal:

Chemical Communications

Species selective diazirine positioning in tag-free photoactive quorum sensing probes†

Luba Dubinsky,a   Antonia Delago,a   Neri Amara,a   Pnina Krief,a   Josep Rayo,a   Tsaffrir Zor,b   Vladimir V. Kravchenkoc  and  Michael M. Meijler*a  

* Corresponding authors

a Department of Chemistry and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel
E-mail: meijler@bgu.ac.il
Tel: +972-8-6472751

b Department of Biochemistry and Molecular Biology, Life Sciences Institute, Tel-Aviv University, Tel-Aviv 69978, Israel

c Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA

Abstract

The synthesis and comparison of activities of ‘tag-free’ probes with diazirines at various positions are described. Remarkable differences in their effects on P. aeruginosa and on human bronchial epithelial cells were observed, supporting the efforts to isolate and identify receptors for N-acyl homoserine lactones.

Graphical abstract: Species selective diazirine positioning in tag-free photoactive quorum sensing probes

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Article information

DOI
https://doi.org/10.1039/C3CC43092H
Article type
Communication
Submitted
26 Apr 2013
Accepted
08 May 2013
First published
10 May 2013

Chem. Commun., 2013,49, 5826-5828

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Species selective diazirine positioning in tag-free photoactive quorum sensing probes

L. Dubinsky, A. Delago, N. Amara, P. Krief, J. Rayo, T. Zor, V. V. Kravchenko and M. M. Meijler, Chem. Commun., 2013, 49, 5826 DOI: 10.1039/C3CC43092H

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