Issue 78, 2013

Allylic C–H alkylation with a CF3-containing nucleophile

Abstract

Allylic C–H alkylation of allylarenes with dimethyl 2-trifluoromethylmalonate was successfully developed. The reactions were carried out at room temperature in the presence of a catalytic amount of Pd(OAc)2/Ph3P and a stoichiometric amount of 2,6-dimethylbenzoquinone. The reactions avoided defluorination successfully, providing a new method to construct a CF3-containing all-carbon quaternary center.

Graphical abstract: Allylic C–H alkylation with a CF3-containing nucleophile

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2013
Accepted
23 Jul 2013
First published
23 Jul 2013

Chem. Commun., 2013,49, 8764-8766

Allylic C–H alkylation with a CF3-containing nucleophile

L. Li, Q. Chen and Y. Guo, Chem. Commun., 2013, 49, 8764 DOI: 10.1039/C3CC43120G

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