One-pot direct C–H arylation of arenes in water catalysed by RuCl3·nH2O–NaOAc in the presence of Zn

Abstract

The inexpensive and commercially available catalytic system RuCl₃·nH₂O–NaOAc–Zn is active in water for the direct C–H arylation of arenes with aryl/heteroaryl chlorides. The reaction can be accelerated by the use of microwave irradiation and can also be scaled up to a multi-gram scale with excellent isolated yields.