Issue 57, 2013

Organocatalytic asymmetric remote aziridination of 2,4-dienals

Abstract

Highly regio- and stereoselective remote aziridination of 2,4-dienals has been developed, based on a vinylogous iminium-ion–dienamine catalytic cascade reaction. Transformations of the aziridine products into enantioenriched motifs are also demonstrated. Furthermore, the reaction concept is extended to include enantioselective 1,6-addition of thiols.

Graphical abstract: Organocatalytic asymmetric remote aziridination of 2,4-dienals

Supplementary files

Article information

Article type
Communication
Submitted
10 May 2013
Accepted
29 May 2013
First published
30 May 2013

Chem. Commun., 2013,49, 6382-6384

Organocatalytic asymmetric remote aziridination of 2,4-dienals

K. S. Halskov, T. Naicker, M. E. Jensen and K. A. Jørgensen, Chem. Commun., 2013, 49, 6382 DOI: 10.1039/C3CC43506G

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