Issue 66, 2013
From the journal:

Chemical Communications

Iron-catalyzed trifluoromethylation with concomitant C–C bond formation via 1,2-migration of an aryl group†

Hiromichi Egami,ab   Ryo Shimizu,ac   Yoshihiko Usuiac  and  Mikiko Sodeoka*abcd  

* Corresponding authors

a Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
E-mail: sodeoka@riken.jp
Fax: +81 48 462 4666

b Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

c Graduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan

d RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Abstract

Iron-catalyzed trifluoromethylation with concomitant 1,2-migration of an aryl group starting from diaryl allyl alcohol was achieved under mild conditions. This reaction system affords α-substituted-β-trifluoromethyl carbonyl compounds in high efficiency. In the case of substrates bearing different aryl groups, selective migration was observed.

Graphical abstract: Iron-catalyzed trifluoromethylation with concomitant C–C bond formation via 1,2-migration of an aryl group

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Article information

DOI
https://doi.org/10.1039/C3CC43936D
Article type
Communication
Submitted
25 May 2013
Accepted
16 Jun 2013
First published
17 Jun 2013

Chem. Commun., 2013,49, 7346-7348

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Iron-catalyzed trifluoromethylation with concomitant C–C bond formation via 1,2-migration of an aryl group

H. Egami, R. Shimizu, Y. Usui and M. Sodeoka, Chem. Commun., 2013, 49, 7346 DOI: 10.1039/C3CC43936D

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