Issue 74, 2013
From the journal:

Chemical Communications

Antioxidant generation and regeneration in lipid bilayers: the amazing case of lipophilic thiosulfinates and hydrophilic thiols†

Feng Zhenga  and  Derek A. Pratt*a  

* Corresponding authors

a Department of Chemistry, University of Ottawa, 10 Marie Curie Pvt., Ottawa, Ontario, Canada
E-mail: dpratt@uottawa.ca
Fax: +1-613-562-5170
Tel: +1-613-562-5800 ext. 2119

Abstract

We demonstrate that the garlic-derived chemopreventive agent allicin and the related anamu-derived petivericin are poor radical-trapping antioxidants in lipid bilayers, but that the in situ reaction of a lipophilic analog and a hydrophilic thiol yields an extremely potent radical-trapping antioxidant that can be recycled in the presence of excess thiol.

Graphical abstract: Antioxidant generation and regeneration in lipid bilayers: the amazing case of lipophilic thiosulfinates and hydrophilic thiols

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Article information

DOI
https://doi.org/10.1039/C3CC44401E
Article type
Communication
Submitted
11 Jun 2013
Accepted
01 Aug 2013
First published
02 Aug 2013

Chem. Commun., 2013,49, 8181-8183

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Antioxidant generation and regeneration in lipid bilayers: the amazing case of lipophilic thiosulfinates and hydrophilic thiols

F. Zheng and D. A. Pratt, Chem. Commun., 2013, 49, 8181 DOI: 10.1039/C3CC44401E

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