Issue 76, 2013
From the journal:

Chemical Communications

Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent†

Swagata Banerjee,a   Jonathan A. Kitchen,‡a   Sandra A. Bright,b   John E. O'Brien,a   D. Clive Williams,*b   John M. Kelly*a  and  Thorfinnur Gunnlaugsson*a  

* Corresponding authors

a School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
E-mail: jmkelly@tcd.ie, gunnlaut@tcd.ie
Tel: +353 1 896 1947

b School of Biochemistry and Immunology and Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland
E-mail: clive.williams@tcd.ie
Tel: +353 1 8962596

Abstract

The bi-functional complex [PtII(terpy)(py-naphth)](NO3)2(1), incorporating both 2,2′:6′,2′′-terpyridine and 4-N,N′-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.

Graphical abstract: Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent

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Article information

DOI
https://doi.org/10.1039/C3CC44962A
Article type
Communication
Submitted
02 Jul 2013
Accepted
01 Aug 2013
First published
01 Aug 2013

Chem. Commun., 2013,49, 8522-8524

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Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent

S. Banerjee, J. A. Kitchen, S. A. Bright, J. E. O'Brien, D. C. Williams, J. M. Kelly and T. Gunnlaugsson, Chem. Commun., 2013, 49, 8522 DOI: 10.1039/C3CC44962A

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