Issue 85, 2013
From the journal:

Chemical Communications

CoCEST: cobalt(ii) amide-appended paraCEST MRI contrast agents†

Sarina J. Dorazio,‡a   Abiola O. Olatunde,‡a   Joseph A. Spernyakb  and  Janet R. Morrow*a  

* Corresponding authors

a Department of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA
E-mail: jmorrow@buffalo.edu

b Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
E-mail: joseph.spernyak@roswellpark.org

Abstract

The first examples of air-stable CoII paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

Graphical abstract: CoCEST: cobalt(ii) amide-appended paraCEST MRI contrast agents

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Article information

DOI
https://doi.org/10.1039/C3CC45000G
Article type
Communication
Submitted
04 Jul 2013
Accepted
02 Sep 2013
First published
17 Sep 2013

Chem. Commun., 2013,49, 10025-10027

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CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents

S. J. Dorazio, A. O. Olatunde, J. A. Spernyak and J. R. Morrow, Chem. Commun., 2013, 49, 10025 DOI: 10.1039/C3CC45000G

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