Issue 82, 2013
From the journal:

Chemical Communications

The use of an engineered single chain variable fragment in a localized surface plasmon resonance method for analysis of the C-reactive protein†

Ju-Young Byun,a   Yong-Beom Shin,b   Taihua Li,a   Jin-Ho Park,a   Dong-Myung Kim,c   Dong-Hwan Choid  and  Min-Gon Kim*a  

* Corresponding authors

a Department of Chemistry, School of Physics and Chemistry and Advanced Photonics Research Institute, Gwangju Institute of Science and Technology (GIST), Korea
E-mail: mkim@gist.ac.kr

b Integrative Cellulomics Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Korea

c Department of Fine Chemical Engineering and Applied Chemistry, Chungnam National University, Korea

d R&D Center, Green Cross Medical Science Corp., Korea

Abstract

A gold nanorod (GNR) based LSPR sensor has been developed for label-free detection of C-reactive protein (CRP). The sensor utilizes a single chain variable fragment (scFv) as a receptor to bind CRP. The results of this effort show that CRP in human serum can be quantitatively detected at lower than 1 ng mL−1.

Graphical abstract: The use of an engineered single chain variable fragment in a localized surface plasmon resonance method for analysis of the C-reactive protein

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Article information

DOI
https://doi.org/10.1039/C3CC45046E
Article type
Communication
Submitted
05 Jul 2013
Accepted
14 Aug 2013
First published
15 Aug 2013

Chem. Commun., 2013,49, 9497-9499

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The use of an engineered single chain variable fragment in a localized surface plasmon resonance method for analysis of the C-reactive protein

J. Byun, Y. Shin, T. Li, J. Park, D. Kim, D. Choi and M. Kim, Chem. Commun., 2013, 49, 9497 DOI: 10.1039/C3CC45046E

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