Issue 72, 2013
From the journal:

Chemical Communications

Amplified detection of DNA by an analyte-induced Y-shaped junction probe assembly followed with a nicking endonuclease-mediated autocatalytic recycling process†

Shufeng Liu,a   Chengxin Zhang,b   Jingjing Ming,b   Chunfeng Wang,b   Tao Liub  and  Feng Li*a  

* Corresponding authors

a College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, 700 Changcheng Road, Qingdao 266109, China
E-mail: lifeng@qust.edu.cn

b College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Abstract

A simple, isothermal and autocatalytic system for the amplified detection of DNA was ingeniously designed based on target-triggered Y-shaped junction probe assembly, followed with a nicking endonuclease-mediated cascade recycling process. A superior detection limit of 0.1 pM towards the target DNA with an excellent selectivity could be achieved.

Graphical abstract: Amplified detection of DNA by an analyte-induced Y-shaped junction probe assembly followed with a nicking endonuclease-mediated autocatalytic recycling process

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Article information

DOI
https://doi.org/10.1039/C3CC45211E
Article type
Communication
Submitted
11 Jul 2013
Accepted
18 Jul 2013
First published
19 Jul 2013

Chem. Commun., 2013,49, 7947-7949

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Amplified detection of DNA by an analyte-induced Y-shaped junction probe assembly followed with a nicking endonuclease-mediated autocatalytic recycling process

S. Liu, C. Zhang, J. Ming, C. Wang, T. Liu and F. Li, Chem. Commun., 2013, 49, 7947 DOI: 10.1039/C3CC45211E

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