Issue 80, 2013

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

Abstract

Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.

Graphical abstract: Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

Supplementary files

Article information

Article type
Communication
Submitted
16 Jul 2013
Accepted
08 Aug 2013
First published
08 Aug 2013

Chem. Commun., 2013,49, 9224-9226

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

X. Dou, W. Yao, B. Zhou and Y. Lu, Chem. Commun., 2013, 49, 9224 DOI: 10.1039/C3CC45369C

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