Issue 9, 2014
From the journal:

Chemical Communications

Microglia specific fluorescent probes for live cell imaging†

Cheryl Leong,ab   Sung Chan Lee,b   Jiyeon Ock,c   Xin Li,c   Peter See,d   Sung Jin Park,b   Florent Ginhoux,d   Seong-Wook Yun*b  and  Young-Tae Chang*bc  

* Corresponding authors

a NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore

b Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis way, #02-02, Singapore 138667
E-mail: yun_seong_wook@sbic.a-star.edu.sg
Fax: +65 6478-9957
Tel: +65 6478-8760

c Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmcyt@nus.edu.sg
Fax: +65 6516-7795
Tel: +65 6516-6774

d Singapore Immunology Network, Agency for Science, Technology and Research, Singapore

Abstract

Small molecule fluorescent probes offer significant advantages over conventional antibody and fluorescent protein labeling techniques. Here we present CDr10a and CDr10b, dyes that label live microglia specifically. They may be applied to the isolation and imaging of live microglia when investigating their role in neuroinflammatory diseases.

Graphical abstract: Microglia specific fluorescent probes for live cell imaging

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Article information

DOI
https://doi.org/10.1039/C3CC45715J
Article type
Communication
Submitted
26 Jul 2013
Accepted
20 Nov 2013
First published
21 Nov 2013

Chem. Commun., 2014,50, 1089-1091

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Microglia specific fluorescent probes for live cell imaging

C. Leong, S. C. Lee, J. Ock, X. Li, P. See, S. J. Park, F. Ginhoux, S. Yun and Y. Chang, Chem. Commun., 2014, 50, 1089 DOI: 10.1039/C3CC45715J

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