Issue 85, 2013
From the journal:

Chemical Communications

A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors†

Anatolie Dobrov,a   Simone Göschl,a   Michael A. Jakupec,a   Ana Popović-Bijelić,b   Astrid Gräslund,c   Peter Raptad  and  Vladimir B. Arion*a  

* Corresponding authors

a Institute of Inorganic Chemistry of the University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria
E-mail: vladimir.arion@univie.ac.at

b Faculty of Physical Chemistry, University of Belgrade, 11158 Belgrade, Serbia

c Department of Biochemistry and Biophysics, Stockholm University, S-10691 Stockholm, Sweden

d Department of Physical Chemistry, Slovak University of Technology, Radlinského 9, SK-81237 Bratislava, Slovak Republic

Abstract

A new paullone–TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

Graphical abstract: A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors

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Article information

DOI
https://doi.org/10.1039/C3CC45743E
Article type
Communication
Submitted
27 Jul 2013
Accepted
03 Sep 2013
First published
03 Sep 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 10007-10009

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A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors

A. Dobrov, S. Göschl, M. A. Jakupec, A. Popović-Bijelić, A. Gräslund, P. Rapta and V. B. Arion, Chem. Commun., 2013, 49, 10007 DOI: 10.1039/C3CC45743E

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