Diastereoselective α-C–H functionalization of aliphatic N-heterocycles: an efficient route to ring fused oxazines

Abstract

A novel method for direct C–H functionalization of saturated N-heterocycles allowing easy access to synthetically as well as biologically important and structurally diverse ring-fused oxazines is developed. The method is operationally simple and highly diastereoselective. Moreover, it is efficient in functionalizing broad classes of both cyclic and acyclic amines including the substrates that are otherwise difficult to functionalize.