Issue 88, 2013

Rescuing recombinant proteins by sequestration into the P22 VLP

Abstract

Here we report the use of a self-assembling protein cage to sequester and solubilize recombinant proteins which are usually trafficked to insoluble inclusion bodies. Our results suggest that protein cages can be used as novel vehicles to rescue and produce soluble proteins that are otherwise difficult to obtain using conventional methods.

Graphical abstract: Rescuing recombinant proteins by sequestration into the P22 VLP

Supplementary files

Article information

Article type
Communication
Submitted
26 Aug 2013
Accepted
23 Sep 2013
First published
24 Sep 2013

Chem. Commun., 2013,49, 10412-10414

Rescuing recombinant proteins by sequestration into the P22 VLP

D. P. Patterson, B. LaFrance and T. Douglas, Chem. Commun., 2013, 49, 10412 DOI: 10.1039/C3CC46517A

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