Issue 95, 2013

Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines

Abstract

Direct catalytic addition of acetonitrile pronucleophiles to thiophosphinoylimines is described. Soft Lewis acid–hard Brønsted base cooperative catalysis is crucial to promote this elusive carbon–carbon bond-forming reaction in an enantioselective fashion.

Graphical abstract: Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
17 Sep 2013
Accepted
10 Oct 2013
First published
10 Oct 2013

Chem. Commun., 2013,49, 11227-11229

Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines

Y. Kawato, N. Kumagai and M. Shibasaki, Chem. Commun., 2013, 49, 11227 DOI: 10.1039/C3CC47117A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements