The Yb(OTf)3 catalyzed [4+2] cycloaddition between donor–acceptor cyclobutanes and nitrosoarenes is disclosed. This method facilitates the synthesis of tetrahydro-1,2-oxazines in good to excellent yields as single diastereomers. Except for a few electron-deficient nitrosoarenes, excellent regioselectivity was observed throughout these studies.
![Graphical abstract: The [4+2] cycloaddition of donor–acceptor cyclobutanes and nitrosoarenes](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C3CC47775D&imageInfo.ImageIdentifier.Year=2014)
N. Vemula, A. C. Stevens, T. B. Schon and B. L. Pagenkopf, Chem. Commun., 2014, 50, 1668 DOI: 10.1039/C3CC47775D
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