Issue 17, 2014
From the journal:

Chemical Communications

Graphene oxide-enabled tandem signal amplification for sensitive SPRi immunoassay in serum†

Weihua Hu,abc   Guangli He,abc   Tao Chen,d   Chun Xian Guo,abc   Zhisong Lu,abc   Jonathan Nimal Selvaraj,e   Yang Liu*e  and  Chang Ming Li*abc  

* Corresponding authors

a Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing, China
E-mail: ecmli@swu.edu.cn
Fax: +8623-68254969
Tel: +8623-68254969

b Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 400715, China

c Faculty of Materials and Energy, Southwest University, Chongqing, China

d Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong, China

e Institute of Agro-products Processing Science and Technology Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-products Processing, Ministry of Agriculture, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China
E-mail: liuyang01@caas.cn

Abstract

A tandem signal amplification using bioconjugated graphene oxide and subsequent silver catalytic deposition for surface plasmon resonance imaging (SPRi) to sensitively and specifically immunoassay tumor biomarkers in serum, achieving a limit of detection down to 100 pg mL−1 with a broad dynamic range for α-Fetoprotein (AFP) is reported.

Graphical abstract: Graphene oxide-enabled tandem signal amplification for sensitive SPRi immunoassay in serum

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Article information

DOI
https://doi.org/10.1039/C3CC47933A
Article type
Communication
Submitted
15 Oct 2013
Accepted
27 Nov 2013
First published
28 Nov 2013

Chem. Commun., 2014,50, 2133-2135

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Graphene oxide-enabled tandem signal amplification for sensitive SPRi immunoassay in serum

W. Hu, G. He, T. Chen, C. X. Guo, Z. Lu, J. N. Selvaraj, Y. Liu and C. M. Li, Chem. Commun., 2014, 50, 2133 DOI: 10.1039/C3CC47933A

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