Issue 15, 2014
From the journal:

Chemical Communications

Structural insights into how 5-hydroxymethylation influences transcription factor binding†

Lukas Lercher,‡a   Michael A. McDonough,‡a   Afaf H. El-Sagheer,bc   Armin Thalhammer,a   Skirmantas Kriaucionis,d   Tom Brown*b  and  Christopher J. Schofield*a  

* Corresponding authors

a Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, Oxford, UK
E-mail: Christopher.schofield@chem.ox.ac.uk

b Department of Chemistry, Chemistry Research Laboratory, Oxford, UK
E-mail: tom.brown@chem.ox.ac.uk

c Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez, Egypt

d Laboratory of Epigenetic Mechanisms, Ludwig Institute for Cancer Research, University of Oxford, ORCRB, Oxford, UK

Abstract

Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson–Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.

Graphical abstract: Structural insights into how 5-hydroxymethylation influences transcription factor binding

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Article information

DOI
https://doi.org/10.1039/C3CC48151D
Article type
Communication
Submitted
24 Oct 2013
Accepted
19 Nov 2013
First published
29 Nov 2013

Chem. Commun., 2014,50, 1794-1796

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Structural insights into how 5-hydroxymethylation influences transcription factor binding

L. Lercher, M. A. McDonough, A. H. El-Sagheer, A. Thalhammer, S. Kriaucionis, T. Brown and C. J. Schofield, Chem. Commun., 2014, 50, 1794 DOI: 10.1039/C3CC48151D

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